Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished!

J Cell Biol. 2022 Jan 3;221(1):e202112057. doi: 10.1083/jcb.202112057. Epub 2021 Dec 20.

Abstract

Heterogeneity in endosomal membrane phospholipid content is emerging as a regulator of endocytic trafficking pathways. Kawasaki et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202103141) demonstrate exchange of endosomal PI4P for PS by ORP10 at ER-endosome contact sites, with the consequent recruitment of endosomal fission factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Endosomes*
  • Mitochondrial Membranes*