Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure

Wenwen Zhang; Xinlu Gao; Xiuxiu Wang; Desheng Li; Yiming Zhao; Tingting Zhang; Jingwen Ne; Binbin Xu; Shuainan Li; Zuke Jiang; Hongyue Sun; Wenya Ma; Fan Yang; Benzhi Cai; Baofeng Yang

doi:10.3389/fcvm.2021.753664

Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure

Front Cardiovasc Med. 2021 Dec 2:8:753664. doi: 10.3389/fcvm.2021.753664. eCollection 2021.

Authors

Wenwen Zhang¹, Xinlu Gao¹, Xiuxiu Wang¹, Desheng Li¹, Yiming Zhao¹, Tingting Zhang¹, Jingwen Ne¹, Binbin Xu¹, Shuainan Li¹, Zuke Jiang¹, Hongyue Sun¹, Wenya Ma¹, Fan Yang^{1

2}, Benzhi Cai^{1

3}, Baofeng Yang^{1

2}

Affiliations

¹ Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
² Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, China.
³ Institute of Clinical Pharmacy, The Heilongjiang Key Laboratory of Drug Research, Harbin Medical University, Harbin, China.

Abstract

Heart failure (HF) is the common consequences of various cardiovascular diseases, often leading to severe cardiac output deficits with a high morbidity and mortality. In recent years, light emitting diodes-based therapy (LEDT) has been widely used in multiple cardiac diseases, while its modulatory effects on cardiac function with HF still remain unclear. Therefore, the objective of this study was to investigate the effects of LED-Red irradiation on cardiac function in mice with HF and to reveal its mechanisms. In this study, we constructed a mouse model of HF. We found that LED-Red (630 nm) was an effective wavelength for the treatment of HF. Meanwhile, the application of LED-Red therapy to treat HF mice improved cardiac function, ameliorate heart morphology, reduced pulmonary edema, as well as inhibited collagen deposition. Moreover, LED-Red therapy attenuated the extent of perivascular fibrosis. Besides, LED-Red irradiation promoted calcium transients in cardiomyocytes as well as upregulated ATP synthesis, which may have positive implications for contractile function in mice with HF. Collectively, we identified that LED-Red exerts beneficial effects on cardiac function in HF mice possibly by promoting the synthesis of ATP.

Keywords: adenosine triphosphate (ATP); cardiomyocyte contractility; heart failure (HF); light emitting diodes (LED); light emitting diodes-based therapy (LEDT).