Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis

Abhishek Vaish; Saseendar Shanmugasundaram; Seon Ae Kim; Dong-Hwan Lee; Asode Ananthram Shetty; Seok Jung Kim

doi:10.1016/j.jcot.2021.101718

Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis

J Clin Orthop Trauma. 2021 Nov 24:24:101718. doi: 10.1016/j.jcot.2021.101718. eCollection 2022 Jan.

Authors

Abhishek Vaish¹, Saseendar Shanmugasundaram², Seon Ae Kim³, Dong-Hwan Lee³, Asode Ananthram Shetty⁴, Seok Jung Kim³

Affiliations

¹ Department of Orthopedics, Indraprastha Apollo Hospitals, New Delhi, India.
² Department of Orthopaedics, Apollo Hospital, Muscat, Oman.
³ Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
⁴ Canterbury Christ Church University, Faculty of Health and Social Sciences, Chatham Maritime, Kent, United Kingdom.

Abstract

Articular cartilage injuries are common. The diagnosis of these injuries is often delayed and may lead to early osteoarthritis. Treatment depends on many factors but mainly on the stage and size of the lesion. The anatomy of articular cartilage is complex, and it is an avascular, aneural, and alymphatic structure. Recently, more emphasis is laid on its anatomy and biomechanics to understand the regeneration process of articular cartilage.

Keywords: Articular cartilage; Joint preservation; Orthobiologics; Osteoarthritis.

Publication types

Review