Recently, the use of assisted reproductive techniques (ART) has witnessed a significant increase worldwide. Although most of these pregnancies have a good prognosis, studies show that ART is associated with a risk of obstetric and perinatal complications, compared to pregnancies conceived spontaneously. It is considered that the risk is directly proportional to the number of transferred embryos, thus multiple pregnancies are an independent risk factor that supports the large-scale implementation of single embryo transfer protocols. Simultaneously, studies report obstetric and perinatal complications in singleton pregnancies obtained after ART and it is not possible to establish whether parental or procedural factors are the causal determinants. The purpose of this article is to summarize the risk of maternal-fetal complications associated with ART.