Automated detection, selection and classification of hippocampal landmark points for the diagnosis of Alzheimer's disease

Abstract

Background and objective: Alzheimer's disease (AD) is a neurodegenerative, progressive, and irreversible disease that accounts for up to 80% of all dementia cases. AD predominantly affects older adults, and its clinical diagnosis is a challenging evaluation process, with imprecision rates between 12 and 23%. Structural magnetic resonance (MR) imaging has been widely used in studies related to AD because this technique provides images with excellent anatomical details and information about structural changes induced by the disease in the brain. Current studies are focused on detecting AD in its initial stage, i.e., mild cognitive impairment (MCI), since treatments for preventing or delaying the onset of symptoms is more effective when administered at the early stages of the disease. This study proposes a new technique to perform MR image classification in AD diagnosis using discriminative hippocampal point landmarks among the cognitively normal (CN), MCI, and AD populations.

Methods: Our approach, based on a two-level classification, first detects and selects discriminative landmark points from two diagnosis populations based on their matching distance compared to a probabilistic atlas of 3-D labeled landmark points. The points are classified using attributes computed in a spherical support region around each point using information from brain probability image tissues of gray matter, white matter, and cerebrospinal fluid as sources of information. Next, at the second level, the images are classified based on a quantitative evaluation obtained from the first-level classifier outputs.

Results: For the CN×MCI experiment, we achieved an AUC of 0.83, an accuracy of 75.58%, with 72.9% of sensitivity and 77.81% of specificity. For the MCI×AD experiment, we achieved an AUC value of 0.73, an accuracy of 69.8%, a sensitivity of 74.09% and specificity of 64.57%. Finally, for the CN×AD, we achieved an AUC of 0.95, an accuracy of 89.24%, with 85.58% of sensitivity and 92.71% of specificity.

Conclusions: The obtained classification results are similar to (or even higher than) other studies that classify AD compared to CN individuals and comparable to those classified patients with MCI.

Keywords: 3-D atlas of salient points; 3-D phase congruency; Classification of Alzheimer’s disease; Magnetic resonance imaging; Structural hippocampi atrophy.