Assessing the relative benefits of imaging with plain radiographs and microCT scanning to diagnose cancer in past populations

Abstract

Objective: To determine the degree to which plain radiographs (x-rays) and microCT scans can improve accuracy in the diagnosis of cancer in human remains from past populations.

Materials: The skeletal remains of 143 individuals from medieval Cambridgeshire, dating from 6th-16th century CE.

Methods: Visual inspection of the skeletons for lesions compatible with malignancy, coupled with plain radiographs and microCT scans of the pelvis, femora and vertebra.

Results: Three individuals had visually apparent metastases on their skeletons. Plain radiographs did not identify further individuals with cancer, but did show further lesions in bones with normal external appearance. MicroCT scans identified cancer in two further individuals with normal visual appearance and normal plain radiographs.

Conclusions: Imaging human skeletal remains increases the detection rate of cancer in human skeletal remains. We found microCT scanning to be a much more sensitive imaging modality than plain radiography. It improved our diagnostic accuracy and enabled us to more reliably distinguish between malignant lesions and taphonomic change.

Significance: Future studies investigating the prevalence and nature of malignancy in past populations would benefit from systematic microCT scanning of pelvis, femora and vertebrae of skeletons to optimise their diagnostic accuracy.

Limitations: MicroCT scanning is more expensive than plain radiographs, and may not be easily accessible to biological anthropologists.

Suggestions for further research: To apply this approach to skeletal series from different time periods and geographical regions, where the types of cancer existing in the local population may differ from those we studied in medieval Britain.

Keywords: Bone malignancy; Computerised tomography; Medieval; Metastases; Oncology; X-rays.