A scoping review of resting-state brain functional alterations in Type 2 diabetes

Anson C M Chau; Ashleigh E Smith; Brenton Hordacre; Saravana Kumar; Eva Y W Cheung; Henry K F Mak

doi:10.1016/j.yfrne.2021.100970

A scoping review of resting-state brain functional alterations in Type 2 diabetes

Front Neuroendocrinol. 2022 Apr:65:100970. doi: 10.1016/j.yfrne.2021.100970. Epub 2021 Dec 16.

Authors

Anson C M Chau¹, Ashleigh E Smith², Brenton Hordacre³, Saravana Kumar⁴, Eva Y W Cheung⁵, Henry K F Mak⁶

Affiliations

¹ Medical Imaging, Medical Radiation Science, Allied Health and Human Performance, University of South Australia, Adelaide, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, Australia. Electronic address: anson.chau@unisa.edu.au.
² Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, Australia. Electronic address: ashleigh.smith@unisa.edu.au.
³ IIMPACT in Health, Allied Health and Human Performance, University of South Australia, Adelaide, Australia. Electronic address: brenton.hordacre@unisa.edu.au.
⁴ IIMPACT in Health, Allied Health and Human Performance, University of South Australia, Adelaide, Australia; Allied Health and Human Performance, University of South Australia, Adelaide, Australia. Electronic address: saravana.kumar@unisa.edu.au.
⁵ School of Medical and Health Sciences, Tung Wah College, Hong Kong. Electronic address: evacheung@twc.edu.hk.
⁶ Department of Diagnostic Radiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong; State Key Laboratory for Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong. Electronic address: makkf@hku.hk.

PMID: 34922997
DOI: 10.1016/j.yfrne.2021.100970

Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) has been actively used in the last decade to investigate brain functional connectivity alterations in Type 2 Diabetes Mellitus (T2DM) to understand the neuropathophysiology of T2DM in cognitive degeneration. Given the emergence of new analysis techniques, this scoping review aims to map the rs-fMRI analysis techniques that have been applied in the literature and reports the latest rs-fMRI findings that have not been covered in previous reviews. Graph theory, the contemporary rs-fMRI analysis, has been used to demonstrate altered brain topological organisations in people with T2DM, which included altered degree centrality, functional connectivity strength, the small-world architecture and network-based statistics. These alterations were correlated with T2DM patients' cognitive performances. Graph theory also contributes to identify unbiased seeds for seed-based analysis. The expanding rs-fMRI analytical approaches continue to provide new evidence that helps to understand the mechanisms of T2DM-related cognitive degeneration.

Keywords: Brain functional connectivity; Brain topological organisation; Neurodegeneration; Resting-state functional magnetic resonance; Type 2 diabetes.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Diabetes Mellitus, Type 2*
Humans
Magnetic Resonance Imaging / methods