The abnormal levels of two biological molecules, dopamine (DA) and Uric acid (UA), in human body are symptoms of diseases such as Parkinson's disease and arrhythmia. A novel lanthanum vanadate and multi-walled carbon nanotubes (LaV-MWCNTs) composite modified glassy carbon electrode (GCE) was developed and utilized as an efficient electrochemical sensor for the simultaneous detection of DA and UA. LaV-MWCNTs composite was successfully fabricated by a facile ultrasonic self-assembly method and identified by means of a series of successive measurements including XPS, XRD, FT-IR and FE-SEM. The LaV-MWCNTs modified GCE shows the concentration linear ranges of DA and UA are 2-100 μΜ using DPV. The limits of detection (LODs; signal-to-noise ratio of 3, S/N = 3) of the LaV-MWCNTs modified GCE sensor for DA and UA were calculated to be 0.046 μM and 0.025 μM, respectively. The feasibility of using the LaV-MWCNTs modified GCE sensor to detect DA and UA in a typical biological fluid, fetal bovine serum, was also evaluated by the standard addition method.
Keywords: Accurate detection; Biological fluid; Biological molecules; Eectrochemical sensor; LaV-MWCNTs composite.
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