Isolation and Sequencing of the First Case of Symptomatic MDR Salmonella enterica Subsp. Enterica ST40 in Human in Italy, July 2020

Microb Drug Resist. 2022 Mar;28(3):378-381. doi: 10.1089/mdr.2021.0249. Epub 2021 Dec 16.

Abstract

Strains of drug-resistant nontyphoidal Salmonella spp. are emerging in livestock worldwide. We describe the first case of symptomatic multidrug-resistant (MDR) Salmonella enterica subsp. enterica in human and the genetic mechanisms at the basis of its antibiotic resistance. To control outbreaks, rapid identification and sequencing are necessary. Proactive research and notification are needed to evaluate the routes of transmission from livestock to humans and risk-management strategies of MDR Salmonella strains.

Keywords: ESBL; Italy; MDR; Salmonella; treatment; whole genome sequencing.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Female
  • Genes, Bacterial
  • Genome, Bacterial
  • Humans
  • Italy
  • Microbial Sensitivity Tests
  • Salmonella / drug effects*
  • Salmonella / genetics*
  • Salmonella Infections / drug therapy
  • Salmonella Infections / genetics*
  • Whole Genome Sequencing

Substances

  • Anti-Bacterial Agents

Supplementary concepts

  • Salmonella enterica subsp. enterica