The Dawn of a New Era in Drug Discovery? Drug Screening and the Increasing Biological Complexity of Testing Models

Chem Res Toxicol. 2022 Jan 17;35(1):5-6. doi: 10.1021/acs.chemrestox.1c00331. Epub 2021 Dec 17.

Abstract

Whole-organism phenotype screening and complex in vitro model technology increase the likelihood in identifying successful lead compounds and lower drug attrition rates at later and more expensive stages of the drug discovery process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Drug Discovery*
  • Drug Evaluation, Preclinical
  • High-Throughput Screening Assays
  • Humans
  • Pharmaceutical Preparations / chemistry*
  • Phenotype
  • Zebrafish

Substances

  • Pharmaceutical Preparations