Proteomic dataset: Profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation

Artemiy S Silantyev; Olga N Bukato; Ivan O Butenko; Anastasia A Chernysheva; Olga V Pobeguts; Alexander E Nosyrev; Olga I Gurina

doi:10.1016/j.dib.2021.107658

Proteomic dataset: Profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation

Data Brief. 2021 Dec 1:39:107658. doi: 10.1016/j.dib.2021.107658. eCollection 2021 Dec.

Authors

Artemiy S Silantyev¹, Olga N Bukato², Ivan O Butenko², Anastasia A Chernysheva¹, Olga V Pobeguts², Alexander E Nosyrev³, Olga I Gurina⁴

Affiliations

¹ Federal State Institution V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology National Scientific Research Centre on Addictions of the Ministry of Healthcare of the Russian Federation, Moscow 119002, Russian Federation.
² Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
³ Center of Bioanalytical Research and Molecular Designm, FSAEI HE I.M. Sechenov First MSMU MOH Russia, Sechenov University, Moscow 119048, Russian Federation.
⁴ Department of Fundamental and Applied Neurobiology, Serbsky National Research Center for Social and Forensic Psychiatry, Ministry of Health and Social Development of the Russian Federation, Moscow 119034, Russian Federation.

Abstract

Human multiforme glioblastoma is characterized by an unfavorable prognosis, low survival rate and extremely limited possibilities for therapy. Rat C6 glioma is an experimental model for the study of glioblastoma growth and invasion. It has been shown that the growth and development of the tumor is accompanied by changes in the surrounding normotypic tissues [1]. These changes create a favorable environment for the development of the tumor and give it an evolutionary advantage [2]. Description of changes occurring in normotypic cells of the body upon their contact with tumor cells is of great interest. We have grown C6 glioma cells and rat astrocytes, as well as astrocyte cells co-cultured together with C6 glioma. We performed proteome-wide LC-MS analysis of these experimental groups. The data includes LC-MS/MS raw files and exported MaxQuant and ProteinPilot search results with fasta. Dataset published in the PRIDE repository project accession PXD026776.

Keywords: Co-culture; Glioma C6; LC-MS/MS; Proteome.