Objective: To explore the correlation of triglyceride-glucose product (TyG) index with chronic kidney disease (CKD) in elderly population in Lanzhou (Gansu Province, China).
Methods: From May to September, 2011, a total of 3868 middleaged and elderly individuals without CKD from 3 communities in Lanzhou were selected as the cohort study population and were followed for an average of 3.1 years (from June, 2014 to August, 2015). After excluding those with missing follow-up data, a total of 3439 individuals were included for analysis, who were divided according to the quartile of TyG index into Q1 group (TyG≤8.47), Q2 group (TyG 8.48-8.84), Q3 group (TyG 8.85-9.20) and Q4 group (TyG>9.20). The estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio (UACR) were used to evaluate the renal function of the participants.
Results: In this cohort, a high TyG index was found to correlate with a high risk of CKD (P < 0.05). Analysis of the follow-up data showed that the TyG index was significantly higher in patients who developed CKD during the follow-up than in those without CKD (P < 0.05). Logistic regression analysis showed that TyG index was an independent risk factor for abnormal eGFR and CKD (P < 0.05).
Conclusion: A high TyG index is an independent risk factor for CKD in middle-aged and elderly population.
目的: 探讨兰州市中老年人甘油三酯-葡萄糖乘积（TyG）指数与慢性肾脏病（CKD）的相关性。
方法: 于2011年5月~2011年9月选取兰州市3个社区非CKD人群3868人建立队列研究人群，于2014年6月~2015年8月进行了平均3.1年的随访，排除随访资料缺失的人群后，共纳入3439人。根据TyG指数四分位数分为Q1组（TyG≤8.47）、Q2组（TyG 8.48~8.84）、Q3组（TyG 8.85~ 9.20）和Q4组（TyG>9.20）。用估计肾小球滤过率（eGFR）和尿白蛋白/尿肌酐（UACR）评价肾功能。
结果: 高TyG指数的人CKD发生率较高（P < 0.05）。随访后发生CKD的患者TyG指数高于非CKD人群（P < 0.05）。Logistic回归分析显示：TyG指数是异常eGFR及CKD发生的独立相关因素（P < 0.05）。
结论: 高TyG指数是CKD发生的独立危险因素。
Keywords: chronic kidney disease; glomerular filtration rate; triglyceride-glucose product index; urine albumin/creatinine.