Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Lu Wen; Ying Li; Siyao Li; Xiaoru Hu; Qingqing Wei; Zheng Dong

doi:10.3389/fmed.2021.744122

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Front Med (Lausanne). 2021 Nov 29:8:744122. doi: 10.3389/fmed.2021.744122. eCollection 2021.

Authors

Lu Wen^{1

2

3}, Ying Li¹, Siyao Li^{1

2

3}, Xiaoru Hu^{1

2

3}, Qingqing Wei^{2

3}, Zheng Dong^{1

2

3}

Affiliations

¹ Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
² Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, United States.
³ Research Department, Charlie Norwood VA Medical Center, Augusta, GA, United States.

Abstract

The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases.

Keywords: SGLTs; glucose metabolism; glycolysis (warburg effect); kidney injury and repair; renal fibrosis.

Publication types

Review