SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults

António Martins; Sílvia Policarpo; André Silva-Pinto; Ana Sofia Santos; Paulo Figueiredo; António Sarmento; Lurdes Santos

doi:10.12890/2021_003025

SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults

Eur J Case Rep Intern Med. 2021 Nov 26;8(11):003025. doi: 10.12890/2021_003025. eCollection 2021.

Authors

António Martins^{1

2}, Sílvia Policarpo^{1

2}, André Silva-Pinto^{1

2

3}, Ana Sofia Santos^{1

2}, Paulo Figueiredo^{1

2}, António Sarmento^{1

2

3}, Lurdes Santos^{1

2

3}

Affiliations

¹ Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
² Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
³ Nephrology and Infectious Diseases R&D, i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal.

Abstract

Adults infected with SARS-CoV-2 may develop a multisystem inflammatory syndrome (MIS-A) characterized by elevated inflammatory markers and multisystem organ involvement. We report the case of a patient who presented with fever and vomiting at hospital admission. He tested positive for SARS-CoV-2 infection and blood tests showed elevated inflammatory markers. The patient developed acute cardiac dysfunction and shock in less than 24 hours and the echocardiogram revealed an LVEF of 30%. He was discharged 3 weeks later fully recovered. MIS-A should be considered if a compatible syndrome is observed in patients with evidence of SARS-CoV-2 infection by PCR test or serology.

Learning points: Multisystem inflammatory syndrome should be considered in young adults presenting with shock and elevated inflammatory markers.Multisystem inflammatory syndrome may be highly responsive to parenteral steroids.

Keywords: SARS-CoV-2; adult patients; multisystem inflammatory syndrome.