Voltammetric detection of sumatriptan in the presence of naproxen using Fe3O4@ZIF-8 nanoparticles modified screen printed graphite electrode

Somayeh Tajik; Mahboobeh Shahsavari; Iran Sheikhshoaie; Fariba Garkani Nejad; Hadi Beitollahi

doi:10.1038/s41598-021-98598-1

Voltammetric detection of sumatriptan in the presence of naproxen using Fe₃O₄@ZIF-8 nanoparticles modified screen printed graphite electrode

Sci Rep. 2021 Dec 15;11(1):24068. doi: 10.1038/s41598-021-98598-1.

Authors

Somayeh Tajik¹, Mahboobeh Shahsavari², Iran Sheikhshoaie², Fariba Garkani Nejad², Hadi Beitollahi³

Affiliations

¹ Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
² Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, 76175-133, Kerman, Iran.
³ Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran. h.beitollahi@yahoo.com.

Abstract

A novel electrochemical sensing platform was designed and prepared for the simultaneous detection of sumatriptan and naproxen by exploiting the prowess of the Fe₃O₄@ZIF-8 nanoparticles (NPs); as-synthesized Fe₃O₄@ZIF-8 NPs were characterized by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy and thermal gravimetric analysis. The immobilized Fe₃O₄@ZIF-8 NPs on a screen printed graphite electrode (SPGE) was evaluated electrochemically via cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry as well as chronoamprometery means; Fe₃O₄@ZIF-8/SPGE exhibited good sensing performance for sumatriptan in a range of 0.035-475.0 µM with detection limit of 0.012 µM. Also, Fe₃O₄@ZIF-8/SPGE exhibited good sensing performance for naproxen in a range of 0.1-700.0 µM with detection limit of 0.03 µM. The modified electrode showed two separate oxidative peaks at 620 mV for sumatriptan and at 830 mV for naproxen with a peak potential separation of 210 mV which was large enough to detect the two drugs simultaneously besides being stable in the long-run with considerable reproducibility. Real sample analyses were carried out to identify the function of fabricated electrode in sensing applications wherein trace amounts of sumatriptan and naproxen could be identified in these samples.