Pancreatic cancer death is increasing with aging of population. Cancer prevention is quite important especially for intractable cancers such as pancreatic cancer. Epidemiological studies have suggested that cigarette smoking, heavy alcohol drinking, chronic pancreatitis, obesity, type 2 diabetes mellitus and family history are risk factors for pancreatic cancer. Fatty pancreas is also a possible risk factor. Therefore, in addition to stop of smoking, improvement of these inflammatory conditions by changing life styles and/or taking medicines is considered to be helpful to prevent pancreatic cancer development. In this article, as candidate chemopreventive agents for pancreatic cancer, anti-inflammatory drugs, anti-diabetic drugs and anti- dyslipidemic drugs are focused on, and the effects of these drugs on pancreatic cancer in humans and experimental animals are described.