Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Affiliations

• ¹ Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
• ² Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
• ³ Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• ⁴ School of Public Health, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
• ⁵ Porter School of Environmental and Earth Sciences, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel.
• ⁶ National Microbiology Reference Unit, Scottish National Blood Transfusion Service, Edinburgh, Edinburgh, UK.
• ⁷ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
• ⁸ Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
• ⁹ Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• ¹⁰ Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
• ¹¹ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• ¹² Department of Gastroenterology, Mount Sinai School of Medicine, New York, New York, USA.
• ¹³ The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
• ¹⁴ Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
• ¹⁵ Warwick Medical School, University of Warwick, Coventry, UK craigpeterthompson@gmail.com.
• ¹⁶ Department of Zoology, University of Oxford, Oxford, UK.