Tfh cells set the stage for tumor control

Abstract

The microbiome has a profound influence on the development and progression of cancer, as well as the response to immunotherapy. In this issue of Immunity, Overacre-Delgoffe et al. (2021) examine the impact of the immunogenic bacteria Helicobacter hepaticus (Hhep) in the immune response to colorectal cancer, providing evidence that T follicular helper (Tfh) cells that specifically recognize Hhep antigens are necessary for the control of tumor growth.