An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations

Suli Jia; Chengquan Wang; Jing Qian; Xingcai Zhang; Haining Cui; Qi Zhang; Yunmeng Tian; Nan Hao; Jie Wei; Kun Wang

doi:10.1039/d1cc05429e

An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations

Chem Commun (Camb). 2022 Jan 4;58(3):467-470. doi: 10.1039/d1cc05429e.

Authors

Suli Jia¹, Chengquan Wang², Jing Qian¹, Xingcai Zhang^{3

4}, Haining Cui¹, Qi Zhang¹, Yunmeng Tian¹, Nan Hao¹, Jie Wei¹, Kun Wang¹

Affiliations

¹ School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China. qianj@ujs.edu.cn.
² School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P. R. China.
³ School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
⁴ School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

PMID: 34908039
DOI: 10.1039/d1cc05429e

Abstract

We demonstrated a new class of 2D nanosheet-based FRET biosensor utilizing vertically oriented MoS₂ nanosheets on a magnetic nanocarrier. Compared with the non-separated biosensor under identical conditions, this upgraded one can avoid the background signal of the system and eliminate the effects of background fluctuations, which produces more excellent detection methods.

MeSH terms

Aflatoxin B1 / analysis*
Biosensing Techniques*
Disulfides / chemistry*
Electrochemical Techniques*
Ferric Compounds / chemistry*
Fluorescence Resonance Energy Transfer*
Molybdenum / chemistry*
Nanostructures / chemistry*
Particle Size

Substances

Disulfides
Ferric Compounds
ferric oxide
Molybdenum
Aflatoxin B1
molybdenum disulfide