Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

Kai-Wei Liao; Fang-Chi Chang; Chia-Huang Chang; Yu-Fang Huang; Wen-Harn Pan; Mei-Lien Chen

doi:10.1016/j.foodchem.2021.131653

Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

Food Chem. 2022 Apr 16:374:131653. doi: 10.1016/j.foodchem.2021.131653. Epub 2021 Nov 24.

Authors

Kai-Wei Liao¹, Fang-Chi Chang², Chia-Huang Chang³, Yu-Fang Huang⁴, Wen-Harn Pan⁵, Mei-Lien Chen⁶

Affiliations

¹ School of Food Safety, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
² Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
³ School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Safety, Health and Environmental Engineering, National United University, Miaoli, Taiwan.
⁵ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: pan@ibms.sinica.edu.tw.
⁶ Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: mlchen@ym.edu.tw.

PMID: 34906800
DOI: 10.1016/j.foodchem.2021.131653

Abstract

We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-acetyl-S-(propionamide)-cysteine (AAMA)] concentrations were analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-ToF-MS). Multiple regression was used to examine associations between AA metabolite levels and dietary patterns. A total of 706 subjects were studied. We found that per increase in weekly frequency of sweetened beverages in the 6-11-years group (β = 0.322, p = 0.018) and oily snacks intakes in the 12-18-years group (β = 0.335, p = 0.012) will increase 10^β of urinary AAMA concentrations. Assuming that 50% of the AA intake is excreted as urinary AAMA, the Monte Carlo simulation showed that 1.75-19.48% among all age groups have exceeded the reference dose of 2 μg/kg-body weight/day.

Keywords: Acrylamide; Dietary pattern; Health risk assessment; Human biomonitoring; N-acetyl-S-(propionamide)-cysteine; Taiwan.

MeSH terms

Acetylcysteine*
Acrylamide*
Chromatography, High Pressure Liquid
Diet
Humans
Taiwan

Substances

Acrylamide
Acetylcysteine