Air pollution control is a worldwide problem of common concern to all mankind. Electrostatic precipitator (ESP) plays an important role in the purification of flue gas and dust. At present, in a multi-electrode ESP, the middle discharge electrode is often inhibited by the outer discharge electrode, commonly known as electrostatic shielding, which seriously affects the electric field distribution and dust removal effect of ESP. In order to explore this characteristic, this research established a mathematical model of ESP and simulated the electrostatic shielding phenomenon of wire-plate ESP, which quantified the influence of various factors on the degree of electrostatic shielding and analyzed the potential impact of electrostatic shielding on particle charging and dust removal efficiency. The results of the study show that the wire-to-plate distance has the greatest impact on electrostatic shielding, followed by the discharge electrode radius, voltage, and the wire-to-wire distance. When the degree of electrostatic shielding increases, the dust removal efficiency of ESP decreases. In addition, increasing the number of discharge electrodes to increase the dust removal efficiency of ESP is only feasible within a certain range. When the number of discharge electrodes exceeds a certain threshold, the dust removal efficiency of ESP decreases due to the effect of electrostatic shielding. The results of the research provide guidance for the determination of the geometric parameters of ESP and can make theoretical predictions for the occurrence of electrostatic shielding, thereby effectively avoiding the occurrence of electrostatic shielding.Implications: Electrostatic precipitator plays an important role in the purification of flue gas and dust. Electrostatic shielding seriously affects the electric field distribution and dust removal effect of ESP. The research quantified the influence of various factors on the degree of electrostatic shielding and analyzed the potential impact of electrostatic shielding on particle charging and dust removal efficiency. It is expected that through the research, some guidance will be provided for the determination of the geometric parameters of ESP and can make theoretical predictions for the occurrence of electrostatic shielding, thereby effectively avoiding the occurrence of electrostatic shielding.