Oh lazy sister, where art thou?

Commun Biol. 2021 Dec 13;4(1):1403. doi: 10.1038/s42003-021-02933-1.

Abstract

Mitotic divisions achieve equal re-partition of chromosomes into daughter cells. In their recent work in Developmental Cell, Sen, Harrison et al. propose that the risk of mis-segregation in human mitotic cells is higher than previously thought and identify the existence of an early-anaphase correction mechanism. The study documents kinetochore dynamics in unprecedented detail, providing a detailed look at the events preceding loss of correct chromosomal numericity and genomic stability.

MeSH terms

  • Anaphase / physiology*
  • Chromosome Segregation / physiology
  • Humans
  • Kinetochores / metabolism*
  • Mitosis / physiology