Magnetic nanoparticles for highly robust, facile and efficient loading of metal-based drugs

J Inorg Biochem. 2022 Feb:227:111685. doi: 10.1016/j.jinorgbio.2021.111685. Epub 2021 Dec 6.

Abstract

Direct interaction between iron oxide nanoparticles (IONs), modified with polyethylene glycol and an ionic liquid, and activated cisplatin drug resulted in a fast and high drug loading (up to 0.17 mol of platinum per gram of iron), and the payload does not strongly affect the magnetic properties of IONs and resists protein adsorption in human serum environment. For another, developmental metal-based drug, tris(8-quinolinolato)gallium(III), binding to the IONs allowed for overcoming the disadvantages of low solubility and incompatibility with intravenous administration. The potential of IONs as a magnetic nanoformulation for smart drug delivery has been confirmed by the release of both metallodrugs under conditions relevant to cancer cytosol.

Keywords: Cisplatin; Drug delivery; Drug loading; Human serum; In vitro release; Magnetic nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes* / chemistry
  • Coordination Complexes* / pharmacokinetics
  • Drug Delivery Systems*
  • Drug Liberation
  • Gallium / chemistry*
  • Humans
  • Magnetite Nanoparticles / chemistry*
  • Serum Albumin, Human / chemistry

Substances

  • Coordination Complexes
  • Magnetite Nanoparticles
  • Gallium
  • Serum Albumin, Human