Endostatin in Renal and Cardiovascular Diseases

Mei Li; Zoran Popovic; Chang Chu; Bernhard K Krämer; Berthold Hocher

doi:10.1159/000518221

Endostatin in Renal and Cardiovascular Diseases

Kidney Dis (Basel). 2021 Sep 9;7(6):468-481. doi: 10.1159/000518221. eCollection 2021 Nov.

Authors

Mei Li¹, Zoran Popovic², Chang Chu^{1

3}, Bernhard K Krämer^{1

4

5}, Berthold Hocher^{1

6

7}

Affiliations

¹ Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.
² Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.
³ Department of Nephrology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
⁴ European Center for Angioscience, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
⁵ Center for Innate Immunoscience, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
⁶ Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.
⁷ Institute of Medical Diagnostics, IMD Berlin, Berlin, Germany.

Abstract

Endostatin, a protein derived from the cleavage of collagen XVIII by the action of proteases, is an endogenous inhibitor known for its ability to inhibit proliferation and migration of endothelial cells, angiogenesis, and tumor growth. Angiogenesis is defined as the formation of new blood vessels from pre-existing vasculature, which is crucial in many physiological processes, such as embryogenesis, tissue regeneration, and neoplasia.

Summary: Increasing evidence shows that dysregulation of angiogenesis is crucial for the pathogenesis of renal and cardiovascular diseases. Endostatin plays a pivotal role in the regulation of angiogenesis. Recent studies have provided evidence that circulating endostatin increases significantly in patients with kidney and heart failure and may also contribute to disease progression.

Key message: In the current review, we summarize the latest findings on preclinical and clinical studies analyzing the impact of endostatin on renal and cardiovascular diseases.

Keywords: Angiogenesis; Cardiovascular diseases; Collagen XVIII; Endostatin; Renal diseases.

Publication types

Review