Location-Specific Radiomics Score: Novel Imaging Marker for Predicting Poor Outcome of Deep and Lobar Spontaneous Intracerebral Hemorrhage

Zhiming Zhou; Hongli Zhou; Zuhua Song; Yuanyuan Chen; Dajing Guo; Jinhua Cai

doi:10.3389/fnins.2021.766228

Location-Specific Radiomics Score: Novel Imaging Marker for Predicting Poor Outcome of Deep and Lobar Spontaneous Intracerebral Hemorrhage

Front Neurosci. 2021 Nov 25:15:766228. doi: 10.3389/fnins.2021.766228. eCollection 2021.

Authors

Zhiming Zhou^{1

2}, Hongli Zhou³, Zuhua Song¹, Yuanyuan Chen¹, Dajing Guo¹, Jinhua Cai^{2

4

5}

Affiliations

¹ Department of Radiology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
² Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China.
³ Nanchong Central Hospital, Nanchong, China.
⁴ Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
⁵ Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.

Abstract

Objective: To derive and validate a location-specific radiomics score (Rad-score) based on noncontrast computed tomography for predicting poor deep and lobar spontaneous intracerebral hemorrhage (SICH) outcome. Methods: In total, 494 SICH patients from multiple centers were retrospectively reviewed. Poor outcome was considered mRS 3-6 at 6 months. The Rad-score was derived using optimal radiomics features. The optimal location-specific Rad-score cut-offs for poor deep and lobar SICH outcomes were identified using receiver operating characteristic curve analysis. Univariable and multivariable analyses were used to determine independent poor outcome predictors. The combined models for deep and lobar SICH were constructed using independent predictors of poor outcomes, including dichotomized Rad-score in the derivation cohort, which was validated in the validation cohort. Results: Of 494 SICH patients, 392 (79%) had deep SICH, and 373 (76%) had poor outcomes. The Glasgow Coma Scale score, haematoma enlargement, haematoma location, haematoma volume and Rad-score were independent predictors of poor outcomes (all P < 0.05). Cut-offs of Rad-score, 82.90 (AUC = 0.794) in deep SICH and 80.77 (AUC = 0.823) in lobar SICH, were identified for predicting poor outcomes. For deep SICH, the AUCs of the combined model were 0.856 and 0.831 in the derivation and validation cohorts, respectively. For lobar SICH, the combined model AUCs were 0.866 and 0.843 in the derivation and validation cohorts, respectively. Conclusion: Location-specific Rad-scores and combined models can identify subjects at high risk of poor deep and lobar SICH outcomes, which could improve clinical trial design by screening target patients.

Keywords: computed tomography; intracerebral hemorrhage; location; prognosis; radiomics.