Development of an Add-on 23Na-MRI Radiofrequency Platform for a 1H-MRI System Using a Crossband Repeater: Proof-of-concept

Magn Reson Med Sci. 2023 Jan 1;22(1):103-115. doi: 10.2463/mrms.tn.2021-0094. Epub 2021 Dec 10.

Abstract

23Na-MRI provides information on Na+ content, and its application in the medical field has been highly anticipated. However, for existing clinical 1H-MRI systems, its implementation requires an additional broadband RF transmitter, dedicated transceivers, and RF coils for Na+ imaging. However, a standard medical MRI system cannot often be modified to perform 23Na imaging. We have developed an add-on crossband RF repeater system that enables 23Na-MRI simply by inserting it into the magnet bore of an existing 1H MRI. The three axis gradient fields controlled by the 1H-MRI system were directly used for 23Na imaging without any deformation. A crossband repeater is a common technique used for amateur radio. This concept was proven by a saline solution phantom and in vivo mouse experiments. This add-on RF platform is applicable to medical 1H MRI systems and can enhance the application of 23Na-MRI in clinical usage.

Keywords: add-on platform; crossband repeater; live mouse imaging; sodium magnetic resonance imaging.

MeSH terms

  • Animals
  • Magnetic Resonance Imaging* / methods
  • Magnets
  • Mice
  • Phantoms, Imaging
  • Radio Waves*