A novel polyhedral oligomeric silsesquioxane-based hybrid monolith as a sorbent for on-line in-tube solid phase microextraction of bisphenols in milk prior to high performance liquid chromatography-ultraviolet detection analysis

Jie Liu; Qian Liu; Liulin Wei; Xiaomei Chen; Zhiqiang Li; Yidong Xu; Xueyun Gao; Xiaoxiao Lu; Jingchan Zhao

doi:10.1016/j.foodchem.2021.131775

A novel polyhedral oligomeric silsesquioxane-based hybrid monolith as a sorbent for on-line in-tube solid phase microextraction of bisphenols in milk prior to high performance liquid chromatography-ultraviolet detection analysis

Food Chem. 2022 Apr 16:374:131775. doi: 10.1016/j.foodchem.2021.131775. Epub 2021 Dec 6.

Authors

Jie Liu¹, Qian Liu¹, Liulin Wei¹, Xiaomei Chen¹, Zhiqiang Li¹, Yidong Xu¹, Xueyun Gao¹, Xiaoxiao Lu¹, Jingchan Zhao²

Affiliations

¹ College of Chemistry and Material Science, Northwest University, Xi'an 710127, China.
² College of Chemistry and Material Science, Northwest University, Xi'an 710127, China. Electronic address: zhaojc@nwu.edu.cn.

PMID: 34896942
DOI: 10.1016/j.foodchem.2021.131775

Abstract

An on-line in-tube solid-phase microextraction (in-tube SPME) coupled with high-performance liquid chromatography (HPLC) method was proposed based on a novel polyhedral oligomeric silsesquioxane (POSS)-hybrid monolith for the determination of four bisphenols (BPs) in milk. The monolith was synthesized using acrylamide (AM) and monomethacrylate-functionalized POSS (mono-MA-POSS) as functional monomers to copolymerize with ethylene dimethacrylate (EDMA). Due to the abundant hydrogen bonding, π-π and hydrophobic interaction sites, the synthetic monolith displayed satisfying extraction performance for target BPs. Under the optimized conditions, the developed on-line in-tube SPME-HPLC method exhibited low limits of detection (LODs) (0.030-0.055 ng mL^-1). The spiked recoveries were between 85.4 % and 111.8 %, and the relative standard deviations (RSDs) were less than 3.5 % for all the analytes. The results showed that the proposed method provided alternative for the analysis of BPs in complex samples.

Keywords: Bisphenols; High performance liquid chromatography; In-tube solid-phase microextraction; Polyhedral oligomeric silsesquioxane-hybrid monolith.

MeSH terms

Animals
Chromatography, High Pressure Liquid
Hydrophobic and Hydrophilic Interactions
Limit of Detection
Milk*
Solid Phase Microextraction*