Ultrasensitive electrochemical detection of furazolidone in biological samples using 1D-2D BiVO4@MoS2 hierarchical nano-heterojunction composites armed electrodes

Selvarasu Maheshwaran; Ramachandran Balaji; Shen-Ming Chen; Yo-Shiuan Chang; Elayappan Tamilalagan; Narendhar Chandrasekar; Selvarajan Ethiraj; Melvin S Samuel; Mohanraj Kumar

doi:10.1016/j.envres.2021.112515

Ultrasensitive electrochemical detection of furazolidone in biological samples using 1D-2D BiVO₄@MoS₂ hierarchical nano-heterojunction composites armed electrodes

Environ Res. 2022 Apr 1:205:112515. doi: 10.1016/j.envres.2021.112515. Epub 2021 Dec 9.

Authors

Selvarasu Maheshwaran¹, Ramachandran Balaji¹, Shen-Ming Chen², Yo-Shiuan Chang¹, Elayappan Tamilalagan¹, Narendhar Chandrasekar³, Selvarajan Ethiraj⁴, Melvin S Samuel⁵, Mohanraj Kumar⁶

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan.
² Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan. Electronic address: smchen78@ms15.hinet.net.
³ Department of Nanoscience and Technology, Sri Ramakrishna Engineering College, Coimbatore, Tamil Nadu, India.
⁴ Department of Genetic Engineering, School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
⁵ Department of Material Science and Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
⁶ Department of Environmental Engineering and Management, Chaoyang University of Technology, Taichung 41349, Taiwan.

PMID: 34896319
DOI: 10.1016/j.envres.2021.112515

Abstract

In this work, the hydrothermally synthesized of BiVO₄@MoS₂ hierarchical nano-heterojunction composite is employed as a novel electrocatalyst for electrochemical sensing of Furazolidone (FZE) drug by modifying the glassy carbon electrodes (GCE). The Raman spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy are used to thoroughly investigate the functional groups, vibrational modes, crystal structure, elemental composition and surface topography of the heterojunction composite. The physical characterization results revealed the successful construction of 1D-2D BiVO₄@MoS₂ hierarchical nano-heterojunction composite. When these unique architectures are reinforced on GCE surface, we achieved an enhanced electroactive surface area of 0.154 cm². The electrochemical performance of 1D-2D BiVO₄@MoS₂ is examined though cyclic voltammetry and differential pulse voltammetry (DPV) analysis. The BiVO₄@MoS₂ composites exhibited an excellent electrocatalytic activity in sensing of FZE with superior linear detection ranges of 0.01-14 and 14-614 μM. The limit of detection (LOD) of the BiVO₄@MoS₂ based sensor is determined to be 2.9 nM which is far superior than other reported FZE sensors. Consequently, it is evident from the investigation that the BiVO₄@MoS₂ based FZE sensor can be recommended for analyzing real time samples like human urine and blood serum with appreciable recovery.

Keywords: Electrocatalysis; Furazolidone; Heterojunction nanocomposites; Real sample analysis; Sensor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Electrochemical Techniques / methods
Electrodes
Furazolidone*
Humans
Limit of Detection
Molybdenum* / chemistry

Substances

Furazolidone
Molybdenum