Synthetic carbohydrate-based cell wall components from Staphylococcus aureus

Francesca Berni; Jacopo Enotarpi; Thijs Voskuilen; Sizhe Li; Gijs A van der Marel; Jeroen D C Codée

doi:10.1016/j.ddtec.2021.01.003

Synthetic carbohydrate-based cell wall components from Staphylococcus aureus

Drug Discov Today Technol. 2020 Dec:38:35-43. doi: 10.1016/j.ddtec.2021.01.003. Epub 2021 Apr 12.

Authors

Francesca Berni¹, Jacopo Enotarpi¹, Thijs Voskuilen¹, Sizhe Li¹, Gijs A van der Marel¹, Jeroen D C Codée²

Affiliations

¹ Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
² Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address: jcodee@chem.leidenuniv.nl.

PMID: 34895639
DOI: 10.1016/j.ddtec.2021.01.003

Abstract

Glycopolymers are found surrounding the outer layer of many bacterial species. The first uses as immunogenic component in vaccines are reported since the beginning of the XX century, but it is only in the last decades that glycoconjugate based vaccines have been effectively applied for controlling and preventing several infectious diseases, such as H. influenzae type b (Hib), N. meningitidis, S. pneumoniae or group B Streptococcus. Methicillin resistant S. aureus (MRSA) strains has been appointed by the WHO as one of those pathogens, for which new treatments are urgently needed. Herein we present an overview of the carbohydrate-based cell wall polymers associated with different S. aureus strains and the related affords to deliver well-defined fragments through synthetic chemistry.

Keywords: Capsular polysaccharides; Synthetic antigens; Teichoic acids.

Publication types

Review

MeSH terms

Carbohydrates
Cell Wall
Methicillin-Resistant Staphylococcus aureus*
Staphylococcus aureus*

Substances

Carbohydrates