H19: A Vital Long Noncoding RNA in the Treatment of Diabetes and Diabetic Complications

Curr Pharm Des. 2022;28(12):1011-1018. doi: 10.2174/1381612827666211210123959.

Abstract

Background: Increasing academic efforts have been made to explore the correlation of long noncoding RNAs (lncRNAs) with human diseases, particularly metabolic diseases like diabetes mellitus. Taking lncRNA H19 as an example, this review intends to reveal the functions and mechanism of lncRNA H19 in diabetes mellitus and diabetic complications.

Methods: The research results associated with lncRNA H19 and diabetes mellitus are collected and summarized on PubMed.

Conclusion: LncRNA H19 is a potential instructive marker for the treatment of diabetes mellitus and diabetic complications.

Keywords: H19; diabetes; diabetic complications; hyperglycemia; long noncoding RNA; miRNA; treatment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Complications* / genetics
  • Diabetes Mellitus* / drug therapy
  • Diabetes Mellitus* / genetics
  • Diabetes Mellitus* / metabolism
  • Humans
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism

Substances

  • H19 long non-coding RNA
  • RNA, Long Noncoding