Influencing factors of depressive symptoms in patients with malignant tumour

Dongmei Wang; Nana He; Yuwu Liu; Rui Pang; Meikereayi Dilixiati; Ainiwaer Wumaier

doi:10.1177/03000605211062450

Influencing factors of depressive symptoms in patients with malignant tumour

J Int Med Res. 2021 Dec;49(12):3000605211062450. doi: 10.1177/03000605211062450.

Authors

Dongmei Wang^{1

2}, Nana He³, Yuwu Liu⁴, Rui Pang², Meikereayi Dilixiati², Ainiwaer Wumaier¹

Affiliations

¹ Department of Pharmacology, Xinjiang Medical University, Urumqi, Xinjiang, China.
² Department of Integrated Traditional Chinese and Western Medicine, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
³ Department of Oncology, Affiliated Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China.
⁴ Morphological Center, College of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, China.

Abstract

Objective: To assess the influencing factors of depressive symptoms in malignant tumour patients.

Methods: Participants were 2079 inpatients with malignant tumour (1291: depressive symptoms; 788 no depressive symptoms). Univariable and multivariable logistic regression were used to evaluate sociodemographic and clinical factors influencing depressive symptoms.

Results: Risk factors were family income ≤5000 yuan (odds ratio [OR]: 4.966, 95% confidence interval [CI]: 2.938-8.395) and 5001-10,000 yuan (OR: 3.111, 95% CI: 1.840-5.260); Karnofsky Performance Status of 70 (OR: 2.783, 95% CI: 1.281-6.042) and 80 (OR: 1.834, 95% CI: 1.139-2.953); disease course ≤1 year; palliative treatment (OR: 2.288, 95% CI: 1.292-4.055); progressive disease (OR: 1.876, 95% CI: 1.284-2.739); pain (OR: 1.973, 95% CI: 1.555-2.505); cancer type: lung (OR: 3.199, 95% CI: 1.938-5.279), oesophagus (OR: 3.288, 95% CI: 1.673-6.464), cervix (OR: 1.542, 95% CI: 1.056-2.253) and partial knowledge of disease condition (OR: 2.366, 95% CI: 1.653-3.385). Return to work (OR: 0.503, 95% CI: 0.348-0.727) and physical exercise (OR: 0.437, 95% CI: 0.347-0.551) were protective against depressive symptoms.

Conclusions: Several factors affected depressive symptoms in malignant tumour patients, including income, disease type and course, palliative treatment, return to work and physical exercise.

Keywords: China; Influencing factor; clinical; depressive symptom; malignant tumour; regression; sociodemographic.

MeSH terms

Depression*
Exercise
Female
Humans
Logistic Models
Neoplasms* / complications
Odds Ratio