Potential Role of Akkermansia muciniphila in Parkinson's Disease and Other Neurological/Autoimmune Diseases

Curr Med Sci. 2021 Dec;41(6):1172-1177. doi: 10.1007/s11596-021-2464-5. Epub 2021 Dec 10.

Abstract

The composition of the gut microbiota, including Akkermansia muciniphila (A. muciniphila), is altered in many neurological diseases and may be involved in the pathophysiological processes of Parkinson's disease (PD). A. muciniphila, a mucin-degrading bacterium, is a potential next-generation microbe that has anti-inflammatory properties and is responsible for keeping the body healthy. As the role of A. muciniphila in PD has become increasingly apparent, we discuss the potential link between A. muciniphila and various neurological diseases (including PD) in the current review.

Keywords: Akkermansia muciniphila; Parkinson’s disease; gut microbiota; neurological diseases.

Publication types

  • Review

MeSH terms

  • Akkermansia
  • Autoimmune Diseases* / physiopathology
  • Gastrointestinal Microbiome*
  • Humans
  • Parkinson Disease* / immunology
  • Parkinson Disease* / physiopathology
  • Verrucomicrobia

Supplementary concepts

  • Akkermansia muciniphila