Photodynamic chitosan functionalized MoS2 nanocomposite with enhanced and broad-spectrum antibacterial activity

Wenbo Cao; Lin Yue; Yin Zhang; Zhouping Wang

doi:10.1016/j.carbpol.2021.118808

Photodynamic chitosan functionalized MoS₂ nanocomposite with enhanced and broad-spectrum antibacterial activity

Carbohydr Polym. 2022 Feb 1:277:118808. doi: 10.1016/j.carbpol.2021.118808. Epub 2021 Oct 25.

Authors

Wenbo Cao¹, Lin Yue², Yin Zhang³, Zhouping Wang⁴

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China. Electronic address: yuelin@jiangnan.edu.cn.
³ Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, PR China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, PR China; Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, P. R. China. Electronic address: wangzp@jiangnan.edu.cn.

PMID: 34893226
DOI: 10.1016/j.carbpol.2021.118808

Abstract

Bacterial infection accompanied by antibiotic resistance leads to the lack of effective antibacterial agents, which has become an imminent problem afflicting people. Therefore, development of highly effective and broad-spectrum disinfecting alternatives to tackle this challenge is of great necessity. In view of the different cell wall structures of bacteria, we designed photodynamic antibacterial system based on chlorin e6 (Ce6) loaded chitosan functionalized molybdenum sulfide (MoS₂) nanocomposites (M-CS-Ce6). The nanocomposite can not only allow Ce6 to enter the cells of Gram-positive bacteria, but also destroy the cell wall permeability of Gram-negative bacteria and enhance the photo-antibacterial effect. 10 μg/mL of M-CS-Ce6 irradiated by 660 nm laser for 5 min, completely killed the target pathogens, exhibiting significantly enhanced photo-antibacterial performance against both Gram-positive and Gram-negative bacteria. Compared with other cationic photodynamic composites, M-CS-Ce6 had stronger and broad-spectrum photo-antibacterial effect. Taken together, M-CS-Ce6 could be a promising and safe broad-spectrum antibacterial agent.

Keywords: Antibacterial activity; Broad-spectrum; M-CS-Ce6 nanocomposite; Photodynamic effect.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Chitosan / chemistry
Chitosan / pharmacology*
Disulfides / chemistry
Disulfides / pharmacology*
Drug Screening Assays, Antitumor
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
HeLa Cells
Humans
Molecular Structure
Molybdenum / chemistry
Molybdenum / pharmacology*
Nanocomposites / chemistry*
Particle Size
Photochemotherapy
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Disulfides
Photosensitizing Agents
Molybdenum
Chitosan
molybdenum disulfide