There are more than 150 types of chemical modifications in RNA, mainly methylation, which are widely distributed in all kinds of RNA, including messenger RNA, transfer RNA, ribosomal RNA, non-coding small RNA and long non-coding RNA. In recent years, the identification of RNA methylation modification enzymes and the development of high-throughput sequencing technology at transcriptome level laid a foundation for revealing the expression and function of genes regulated by chemical modification of RNA. In this review, the most recent advances of RNA methylation, especially N6-methyladenosine (m6a) in the blood system, including the regulation of RNA methyltransferases, RNA demethylases and RNA binding proteins on normal and malignant hematopoiesis through the regulation of RNA methylation level were summarized briefly.
题目: 6-甲基腺嘌呤RNA甲基化对造血调控作用的研究进展.
摘要: RNA存在150多种化学修饰，其中以甲基化为主，广泛分布于信使RNA、转运RNA、核糖体RNA、非编码小RNA和长链非编码RNA等各类RNA上。近年来，RNA甲基化修饰酶的鉴定以及转录组水平高通量测序技术的发展为揭示RNA化学修饰如何调控基因的表达和功能奠定了基础。本综述主要总结了有关RNA甲基化，尤其是6-甲基腺嘌呤（m6a）在血液系统中的相关进展，包括RNA甲基转移酶、RNA去甲基酶以及RNA结合蛋白通过RNA甲基化水平的调节从而发挥对正常造血和恶性造血的调控作用。.