When ultraviolet radiation is absorbed within the cutaneous tissues, it can trigger a number of phenomena that can have detrimental or beneficial consequences to an individual's health. Tanning is among the most visually noticeable of these phenomena. It may result in significant changes in skin pigmentation and thickness. These spectrally-dependent physiological responses, in turn, can elicit variations in the ultraviolet absorption profiles of the cutaneous tissues and, consequently, alter the occurrence of other ultraviolet-induced photobiological processes such as the breaking of DNA strands and the synthesis of previtamin D3. These tanning-elicited variations in the cutaneous tissues' absorption profiles is often tied to the increased presence of melanin throughout these tissues. However, during the tanning, shifts in the relative content of this pigment within certain skin layers can also be observed. In particular, the stratum basale, the innermost epidermal layer where melanogenesis takes place, can have its relative melanin content significantly reduced in comparison with other epidermal layers. Since the aforementioned photobiological phenomena are preferentially brought about within this layer, such pigmentation shifts may have a more pivotal role in skin photobiology than has been assumed to date. Accordingly, in this work, we investigate the impact of spectrally-dependent tanning-elicited physiological responses, with a particular focus on the inter-layer melanin distribution patterns, on the absorption profiles of the main cutaneous tissues. We also examine how variations in these absorption profiles may alter the outcomes of photo-triggered phenomena associated with the onset of different medical conditions. Our findings are expected to contribute to the advance of the current understanding about skin photobiology, which is indispensable for the success of photomedicine initiatives involving this highly complex organ.