The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy

J Cell Biol. 2022 Jan 3;221(1):e202111008. doi: 10.1083/jcb.202111008. Epub 2021 Dec 10.

Abstract

A recent study by Zheng et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonstrate that the Torin1-dependent induction of pexophagy is executed by the MARCH5-catalyzed ubiquitination of the peroxisomal membrane protein PMP70.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Macroautophagy
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Peroxisomes* / metabolism
  • Ubiquitin-Protein Ligases* / genetics
  • Ubiquitin-Protein Ligases* / metabolism
  • Ubiquitination

Substances

  • Membrane Proteins
  • Ubiquitin-Protein Ligases