In Sickness and in Health: The Oxygen Reactive Species and the Bone

Joana Reis; António Ramos

doi:10.3389/fbioe.2021.745911

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Front Bioeng Biotechnol. 2021 Nov 23:9:745911. doi: 10.3389/fbioe.2021.745911. eCollection 2021.

Authors

Joana Reis¹, António Ramos²

Affiliations

¹ Agronomic and Veterinary Sciences, School of Agriculture, Polytechnic Institute of Viana Do Castelo, Ponte de Lima, Portugal.
² TEMA, Mechanical Engineering Department, University of Aveiro, Aveiro, Portugal.

Abstract

Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.

Keywords: bone; mechanobiology; mechanotransduction; oxidative stress; redox balance.

Publication types

Review