Diagnostic Challenge and Therapeutic Approaches in Human Sepsis Based on the Appearance of Endotoxemia and Beta-d-Glucanemia

Hiroshi Tamura; Yoshiyuki Adachi

doi:10.3390/ijms222312900

Diagnostic Challenge and Therapeutic Approaches in Human Sepsis Based on the Appearance of Endotoxemia and Beta-d-Glucanemia

Int J Mol Sci. 2021 Nov 29;22(23):12900. doi: 10.3390/ijms222312900.

Authors

Hiroshi Tamura^{1

2}, Yoshiyuki Adachi³

Affiliations

¹ LPS Consulting Office, Tokyo 160-0023, Japan.
² Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
³ Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Abstract

Circulating endotoxin, also called lipopolysaccharide (LPS) and (1→3)-β-d-Glucan (β-d-glucan), major constituents of bacterial and fungal cell walls, respectively, are determined as biomarkers for Gram-negative sepsis and invasive fungal diseases [...].

Publication types

Editorial

MeSH terms

Cell Wall / chemistry
Endotoxemia / diagnosis*
Endotoxemia / metabolism*
Fungi / isolation & purification
Gram-Negative Bacteria / isolation & purification
Gram-Negative Bacterial Infections / diagnosis
Gram-Negative Bacterial Infections / metabolism
Humans
Invasive Fungal Infections / diagnosis*
Invasive Fungal Infections / metabolism
Proteoglycans / metabolism*
Sepsis / diagnosis*
Sepsis / drug therapy
Sepsis / metabolism
Sepsis / microbiology

Substances

Proteoglycans
polysaccharide-K