One Year Assessment of the Hearing Preservation Potential of the EVO Electrode Array

Nicolas Guevara; Cécile Parietti-Winkler; Benoit Godey; Valerie Franco-Vidal; Dan Gnansia; Marine Ardoint; Michel Hoen; Chadlia Karoui; Eric Truy; Christophe Vincent; Isabelle Mosnier; Yann Nguyen

doi:10.3390/jcm10235604

One Year Assessment of the Hearing Preservation Potential of the EVO Electrode Array

J Clin Med. 2021 Nov 29;10(23):5604. doi: 10.3390/jcm10235604.

Authors

Nicolas Guevara¹, Cécile Parietti-Winkler^{2

3}, Benoit Godey⁴, Valerie Franco-Vidal⁵, Dan Gnansia⁶, Marine Ardoint⁶, Michel Hoen⁶, Chadlia Karoui⁶, Eric Truy^{7

8}, Christophe Vincent⁹, Isabelle Mosnier¹⁰, Yann Nguyen^{10

11}

Affiliations

¹ Institut Universitaire de la Face et du Cou (University Institute of the Face and Neck), Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, 06000 Nice, France.
² Service d'ORL et CCF, CHU Nancy, 54000 Nancy, France.
³ Laboratoire Développement, Adaptation et Handicap (DevAH-EA 3450), Faculty of Medicine and Faculty of Sciences and Sport, University of Lorraine, Vandoeuvre-lès-Nancy, 54000 Nancy, France.
⁴ Department of Otolaryngology, Head Neck Surgery, University Hospital Ponchaillou, 35000 Rennes, France.
⁵ Ear, Nose, and Throat Department, Bordeaux University Hospital, 33000 Bordeaux, France.
⁶ Research & Technology, Oticon Medical, Technologies and Gene Therapy for Deafness, Hearing Institute, Institut Pasteur/Inserm, 16096 Paris, France.
⁷ Service d'ORL, De Chirurgie Cervico-Faciale et D'audiophonologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Université de Lyon, 69000 Lyon, France.
⁸ Centre de Recherches en Neurosciences de Lyon, Équipe IMPACT, INSERM UMRS1028 CNRS UMR5292, 69000 Lyon, France.
⁹ Otology and Oto-Neurology Department, Lille University Hospital, 59000 Lille, France.
¹⁰ ENT Department, Pitié Salpêtrière Hospital, APHP/Sorbonne Université, 75013 Paris, France.
¹¹ Institut de L'audition Pasteur/Inserm UMR 1120, 75012 Paris, France.

Abstract

Background: A prospective longitudinal multicentre study was conducted to assess the one-year postsurgical hearing preservation profile of the EVO^TM electrode array.

Methods: Fifteen adults presenting indications of electro-acoustic stimulation (pure-tone audiometry (PTA) thresholds ≤70 dB below 750 Hz) were implanted with the EVO™ electrode array. Hearing thresholds were collected at five time-points from CI activation to twelve months (12M) after activation. Hearing thresholds and hearing preservation profiles (HEARRING group classification) were assessed.

Results: All subjects had measurable hearing thresholds at follow-up. No case of complete loss of hearing or minimal hearing preservation was reported at any time point. At activation (N_act = 15), five participants had complete hearing preservation, and ten participants had partial hearing preservation. At the 12M time point (N_12m = 6), three participants had complete hearing preservation, and three participants had partial hearing preservation. Mean hearing loss at activation was 11 dB for full range PTA and 25 dB for PTAs low-frequency (125-500 Hz).

Conclusions: This study provides the first longitudinal follow-up on associated hearing profiles to the EVO™ electrode array, which are comparable to the literature. However, other studies on larger populations should be performed.

Keywords: EVO electrode array; HEARRING classification; cochlear implantation; functional hearing; hearing preservation.