The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis

Jiehong Huang; Ruoyu Li; Lixi Li; Yunping Song; Lingjing Jin

doi:10.1016/j.neubiorev.2021.12.004

The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis

Neurosci Biobehav Rev. 2022 Jan:132:362-377. doi: 10.1016/j.neubiorev.2021.12.004. Epub 2021 Dec 6.

Authors

Jiehong Huang¹, Ruoyu Li¹, Lixi Li², Yunping Song³, Lingjing Jin⁴

Affiliations

¹ Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; Fundamental Research Center, Department of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
² Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
³ Fundamental Research Center, Department of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. Electronic address: igosong@hotmail.com.
⁴ Fundamental Research Center, Department of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; Shanghai Clinical Research Center for Aging and Medicine, Shanghai, 200040, China. Electronic address: lingjingjin@163.com.

PMID: 34883165
DOI: 10.1016/j.neubiorev.2021.12.004

Abstract

This systematic review aims to 1) explore the association between tic disorders (TD) and allergic diseases (AD), 2) judge whether patients with a diagnosis of TD are prone to suffer from a specific AD, by compiling the literature and analyzing the evidence. A literature search was conducted in PubMed and Embase database on February 24, 2021. The inclusion criteria for the literature were all comparative studies that reported TD patients were diagnosed with allergic illness as well. We identified that TD is positively associated with asthma, allergic rhinitis and allergic conjunctivitis, respectively. Especially, provisional tic disorder (PTD) patients might be more likely to suffer from these three AD, although it is still difficult to accurately predict which specific AD is prone to be accompanied by a specific TD. Shared genetic and etiological factors are suggested responsible for the AD-TD association. Large prospective cohort studies in future might shed light on a deep understanding of the relationship between immune disorders and tics.

Keywords: Allergic conjunctivitis; Allergic dermatitis; Allergic rhinitis; Asthma; Tic disorders.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Asthma*
Humans
Prospective Studies
Rhinitis, Allergic* / complications
Tic Disorders*
Tics*