Local image descriptor learning has been instrumental in various computer vision tasks. Recent innovations lie with similarity measurement of descriptor vectors with metric learning for randomly selected Siamese or triplet patches. Local image descriptor learning focuses more on hard samples since easy samples do not contribute much to optimization. However, few studies focus on hard samples of image patches from the perspective of loss functions and design appropriate learning algorithms to obtain a more compact descriptor representation. This article proposes a regularized descriptor learning network (RDLNet) that makes the network focus on the learning of hard samples and compact descriptor with triplet networks. A novel hard sample mining strategy is designed to select the hardest negative samples in mini-batch. Then batch margin loss concerned with hard samples is adopted to optimize the distance of extreme cases. Finally, for a more stable network and preventing network collapsing, orthogonal regularization is designed to constrain convolutional kernels and obtain rich deep features. RDLNet provides a compact discriminative low-dimensional representation and can be embedded in other pipelines easily. This article gives extensive experimental results for large benchmarks in multiple scenarios and generalization in matching applications with significant improvements.