High-resolution MRI data of the brain of C57BL/6J and BTBR mice in three anatomical views

Yulia A Ryabushkina; Oleg B Shevelev; Polina E Kisaretova; Nikita G Sozonov; Kseniya A Ayriyants; Natalya P Bondar; Vasiliy V Reshetnikov

doi:10.1016/j.dib.2021.107619

High-resolution MRI data of the brain of C57BL/6J and BTBR mice in three anatomical views

Data Brief. 2021 Nov 20:39:107619. doi: 10.1016/j.dib.2021.107619. eCollection 2021 Dec.

Authors

Yulia A Ryabushkina¹, Oleg B Shevelev¹, Polina E Kisaretova^{1

2}, Nikita G Sozonov^{1

2}, Kseniya A Ayriyants¹, Natalya P Bondar^{1

2}, Vasiliy V Reshetnikov^{1

3}

Affiliations

¹ Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia.
² Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
³ Sirius University of Science and Technology, 1 Olympic Avenue, Sochi 354340, Russia.

Abstract

The research on strain-, sex-, and stress-specific differences in structural and functional connectivity of the brain is important for elucidating various behavioral features and etiologies of psychiatric disorders. Socially impaired BTBR mice are considered a model of autism spectrum disorders. Here we present high-resolution magnetic resonance imaging data from the brain of 89 adolescent mice (C57BL/6J and BTBR) in axial, sagittal, and coronal views. The study [1] includes both females and males differed in early-life experience (normally reared or subjected to prolonged maternal separation: 3 h daily from postnatal day 2 to 15). The MRI data were obtained on a horizontal tomograph Biospec 117/16 instrument with a magnetic field strength of 11.7 T. Thus, multislice Turbo RARE T₂-weighted images of the brain were captured in eight groups of mice. Altogether, these data allow to evaluate strain-, sex-, and stress-specific alterations in the volumes of various brain structures and to better understand the relation between brain structural differences and behavioral abnormalities.

Keywords: BTBR; Brain anatomy; C57BL/6J; Early-life stress; MRI; Sex-specific; Strain-specific.