Background: Previous studies have reported that there may be a close relationship between elevated serum uric acid (UA) levels and metabolic syndrome. However, the association between these two factors has not been explored explicitly. Therefore, we carried out this study to investigate the association between UA and lipid profiles.
Methods: A total of 2,482 subjects participated in this cross-sectional study using a multistage stratified sampling method. Lipid profile, glucose metabolism, and other metabolic factors were measured and classified into UA-stratified and age-stratified groups to investigate the relationship between hyperuricemia and metabolic factors. Pearson correlations and logistic regressions were utilized to further explore the association between UA and lipid profile.
Results: The individuals aged 18 to 29 years presented with high serum UA concentrations. Moreover, the prevalence of hyperuricemia was higher among men than in women. Furthermore, statistically significant positive correlations were found between UA and serum triglycerides (TG), serum total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c). Conversely, only high-density lipoprotein cholesterol (HDL-c) was negatively correlated. Moreover, TG group status (1.70≤ TG <2.30 mmol/L) was an independent risk factor for hyperuricemia in both univariate and multivariate models.
Conclusions: This study found significant positive associations between TG, TC, LDL, and UA but an inverse relationship with HDL-c. Thus hyperuricemia may be a risk factor for abnormal lipid metabolism.
Keywords: Serum uric acid (UA); dyslipidemia; hyperuricemia; lipid profile; metabolic diseases.