The heart, an endocrine gland: Natriuretic peptides

Madleen Lemaitre; Arnaud Jannin; Benjamin Chevalier; Marie-Christine Vantyghem

doi:10.1016/j.ando.2021.11.006

The heart, an endocrine gland: Natriuretic peptides

Ann Endocrinol (Paris). 2022 Feb;83(1):59-62. doi: 10.1016/j.ando.2021.11.006. Epub 2021 Dec 3.

Authors

Madleen Lemaitre¹, Arnaud Jannin¹, Benjamin Chevalier¹, Marie-Christine Vantyghem²

Affiliations

¹ Endocrinology, Diabetology and Metabolism Department, Université de Lille, CHU de Lille, Lille, France.
² Endocrinology, Diabetology and Metabolism Department, Université de Lille, CHU de Lille, Lille, France; Inserm U1190, 59000 Lille, France. Electronic address: mc-vantyghem@chru-lille.fr.

PMID: 34871602
DOI: 10.1016/j.ando.2021.11.006

Abstract

The natriuretic peptide family consists of three biologically active peptides: atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). ANP and BNP, secreted by the heart, act as cardiac hormones, whereas CNP is an endothelial peptide. The aim of this manuscript is to review the production, action mechanisms, effects and clinical applications of natriuretic peptides.

Keywords: ANP; Achondroplasia; Achondroplasie; BNP; Clearance receptor; Heart failure; Insuffisance cardiaque; Natriuretic peptide; Peptides natriurétiques ANP; Récepteur de clearance.

Publication types

Review

MeSH terms

Animals
Atrial Natriuretic Factor / metabolism
Cardiovascular Diseases / metabolism*
Endocrine Glands / metabolism*
Humans
Natriuretic Peptide, Brain / metabolism
Natriuretic Peptide, C-Type / metabolism
Natriuretic Peptides / metabolism*

Substances

NPPA protein, human
Natriuretic Peptides
Natriuretic Peptide, Brain
Natriuretic Peptide, C-Type
Atrial Natriuretic Factor