Molecular recognition and photoprotection of riboflavin in water by a biomimetic host

Hong Zhang; Li-Li Wang; Xin-Yu Pang; Liu-Pan Yang; Wei Jiang

doi:10.1039/d1cc05818e

Molecular recognition and photoprotection of riboflavin in water by a biomimetic host

Chem Commun (Camb). 2021 Dec 16;57(100):13724-13727. doi: 10.1039/d1cc05818e.

Authors

Hong Zhang¹, Li-Li Wang^{1

2}, Xin-Yu Pang¹, Liu-Pan Yang¹, Wei Jiang¹

Affiliations

¹ Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis and Department of Chemistry, Southern University of Science and Technology, Xueyuan Blvd 1088, Shenzhen, 518055, China. yanglp@sustech.edu.cn.
² Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study&Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China. liliwang616@163.com.

PMID: 34871338
DOI: 10.1039/d1cc05818e

Abstract

A water-soluble tetralactam macrocycle with 2,6-diethoxynaphthalene groups as side walls is able to strongly bind riboflavin (K_a >10⁷ M^-1) in water through hydrogen bonding and the hydrophobic effect. The encapsulated riboflavin can be stabilized by the host against photo-degradation under UV-vis irradiation, which may be harnessed to extend the shelf life of riboflavin.