Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Masao Nakayama; Hiroaki Akasaka; Eiichi Miyazaki; Yoshihiro Goto; Yuya Oki; Yosuke Kawate; Kenta Morita; Ryohei Sasaki

doi:10.1016/j.phro.2021.11.003

Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Phys Imaging Radiat Oncol. 2021 Nov 23:20:94-97. doi: 10.1016/j.phro.2021.11.003. eCollection 2021 Oct.

Authors

Masao Nakayama^{1

2}, Hiroaki Akasaka^{2

3}, Eiichi Miyazaki¹, Yoshihiro Goto⁴, Yuya Oki³, Yosuke Kawate³, Kenta Morita⁵, Ryohei Sasaki²

Affiliations

¹ Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.
² Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan.
³ Division of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan.
⁴ Department of Radiology, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.
⁵ Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo 657-8501, Japan.

Abstract

Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.

Keywords: IGRT; Nanoparticles; Theranostics; Titanium peroxide.