MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure

Huatao Zhou; Weijie Tang; Jinfu Yang; Jun Peng; Jianjun Guo; Chengming Fan

doi:10.3389/fcvm.2021.773083

MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure

Front Cardiovasc Med. 2021 Nov 19:8:773083. doi: 10.3389/fcvm.2021.773083. eCollection 2021.

Authors

Huatao Zhou¹, Weijie Tang¹, Jinfu Yang^{1

2}, Jun Peng², Jianjun Guo³, Chengming Fan^{1

2

3}

Affiliations

¹ Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
² Department of Pharmacology, Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
³ Hunan Fangsheng Pharmaceutical Co., Ltd. Changsha, China.

Abstract

Heart failure (HF) describes a group of manifestations caused by the failure of heart function as a pump that supports blood flow through the body. MicroRNAs (miRNAs), as one type of non-coding RNA molecule, have crucial roles in the etiology of HF. Accordingly, miRNAs related to HF may represent potential novel therapeutic targets. In this review, we first discuss the different roles of miRNAs in the development and diseases of the heart. We then outline commonly used miRNA chemical modifications and delivery systems. Further, we summarize the opportunities and challenges for HF-related miRNA therapeutics targets, and discuss the first clinical trial of an antisense drug (CDR132L) in patients with HF. Finally, we outline current and future challenges and potential new directions for miRNA-based therapeutics for HF.

Keywords: heart failure; microRNA; modification; non-coding RNA; therapy.

Publication types

Review