Nanotechnology-Based Weapons to Combat Human Papillomavirus Infection Associated Diseases

Luyao Pan; Bingxin Li; Jiahua Chen; Haofeng Zhang; Xi Wang; Jiahui Shou; Dejun Yang; Xiaojian Yan

doi:10.3389/fchem.2021.798727

Nanotechnology-Based Weapons to Combat Human Papillomavirus Infection Associated Diseases

Front Chem. 2021 Nov 17:9:798727. doi: 10.3389/fchem.2021.798727. eCollection 2021.

Authors

Luyao Pan¹, Bingxin Li¹, Jiahua Chen¹, Haofeng Zhang¹, Xi Wang¹, Jiahui Shou¹, Dejun Yang², Xiaojian Yan¹

Affiliations

¹ Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
² School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.

Abstract

Persistent human papillomavirus (HPV) infection will eventually lead to clinical problems, varying from verrucous lesions to malignancies like cervical cancer, oral cancer, anus cancer, and so on. To address the aforementioned problems, nanotechnology-based strategies have been applied to detect the virus, prevent the interaction between virus and mammalian cells, and treat the virus-infected cells, due mainly to the unique physicochemical properties of nanoparticles. In this regard, many nanotechnology-based chemotherapies, gene therapy, vaccination, or combination therapy have been developed. In this Minireview, we outline the pathogenesis of HPV infection and the recent advances in nanotechnology-based weapons that can be applied in combating HPV-associated diseases.

Keywords: HPV; detection; nanomaterials; nanotechnology; treatment.

Publication types

Review