Tissue Engineering Strategies for Peripheral Nerve Regeneration

Yin Li; Zhenjiang Ma; Ya Ren; Dezhi Lu; Tao Li; Wentao Li; Jinwu Wang; Hui Ma; Jie Zhao

doi:10.3389/fneur.2021.768267

Tissue Engineering Strategies for Peripheral Nerve Regeneration

Front Neurol. 2021 Nov 16:12:768267. doi: 10.3389/fneur.2021.768267. eCollection 2021.

Authors

Yin Li¹, Zhenjiang Ma¹, Ya Ren², Dezhi Lu³, Tao Li⁴, Wentao Li¹, Jinwu Wang¹, Hui Ma¹, Jie Zhao¹

Affiliations

¹ Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Southwest JiaoTong University College of Medicine, Chengdu, China.
³ School of Medicine, Shanghai University, Shanghai, China.
⁴ Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Abstract

A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an important role. It develops an ideal nerve substitute called artificial nerve. Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. Moreover, we discussed the scaffolds and seed cells for neural tissue engineering. Furthermore, we have emphasized the role of 3D printing in tissue engineering.

Keywords: 3D printing; cells; nerve tissue engineering; pathophysiology; peripheral nerve regeneration; scaffolds.

Publication types

Review