Dysbiosis in the Human Microbiome of Cholangiocarcinoma

Benchen Rao; Tong Ren; Xuemei Wang; Haiyu Wang; Yawen Zou; Ying Sun; Shanshuo Liu; Zhigang Ren; Zujiang Yu

doi:10.3389/fphys.2021.715536

Dysbiosis in the Human Microbiome of Cholangiocarcinoma

Front Physiol. 2021 Nov 12:12:715536. doi: 10.3389/fphys.2021.715536. eCollection 2021.

Authors

Benchen Rao^{1

2}, Tong Ren³, Xuemei Wang^{1

2}, Haiyu Wang^{1

2}, Yawen Zou^{1

2}, Ying Sun^{1

2}, Shanshuo Liu^{1

2}, Zhigang Ren^{1

2}, Zujiang Yu^{1

2}

Affiliations

¹ Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Cholangiocarcinoma (CCA) is the most common malignant tumor of the biliary system with a very poor prognosis. The human microbiome, which is the sum of the genetic information of human microorganisms, plays an important role in regulating the digestion, absorption, immune response, and metabolism of the host. Increasing evidence indicates a close relationship between CCA and the human microbiome. Specific alterations occur in the human microbiome of patients with CCA. Therefore, in this review, we aimed to summarize the recent evidence on dysbiosis in the human microbiome of CCA. Then, we generalized the effect of Helicobacter pylori on CCA. Additionally, the potential mechanism of human microbial dysbiosis promoted the progress of CCA, and its precancerous disease was also explored. Furthermore, the possibility of the human microbiome as a diagnostic and therapeutic target of CCA was discussed.

Keywords: bile microbiome; cholangiocarcinoma (CCA); gut microbiome; human microbiome; microbial dysbiosis.

Publication types

Review